3-Acylindole derivatives, preparation and therapeutic use...

Details 3-Acylindole derivatives, preparation and therapeutic use... 3-Acylindole derivatives, preparation and therapeutic use...

2008-05-14

2010-06-22

Shameem, Golam M. M. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S493000

Reexamination Certificate

active

07741363

ABSTRACT:
The invention relates to compounds of formula (I), wherein X, R1, R2, R3, R4and R5are as described herein.The invention also includes preparative methods for the preparation of compounds of formula (I). A method for the therapeutic use of the inventive compounds is also disclosed and claimed.

REFERENCES:
patent: 5532237 (1996-07-01), Gallant et al.
patent: 6995184 (2006-02-01), Barth et al.
patent: WO 02/42269 (2002-05-01), None
patent: WO 03/097597 (2003-11-01), None
patent: WO 2006/069196 (2006-06-01), None
Morissette et al. “High-throughput crystallization: polymorphs, salts, co-crystals and solvates of pharmaceutical solids.” Advanced Drug Delivery Reviews 2004, 56, 275-300.
Vippagunta, Sudha R. “Crystalline Solids.” Advanced Drug Delivery Reviews 48(2001): 3-26.
Huffman, J. W., et. al., 1-Pentyl-3-Phenylacetylindoles, a new class of cannabimimetic indoles, Bioorganic & Medicinal Chemistry Letters, vol. 15, (2005) pp. 4110-4113.

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