3-acylamino-2-oxo-1-azetidinyl esters of phosphonic acids, phosp

Details 3-acylamino-2-oxo-1-azetidinyl esters of phosphonic acids, phosp 3-acylamino-2-oxo-1-azetidinyl esters of phosphonic acids, phosp

1982-09-27

1987-07-21

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07F 965, A61K 31675

Patent

active

046819371

ABSTRACT:
Antimicrobial activity is exhibited by .beta.-lactams having a ##STR1## substituent in the 1-position and an acylamino substituent in the 3-position, or a pharmaceutically acceptable salt thereof; wherein Y is oxygen or sulfur and R.sub.5 is hydroxyl, alkyl, substituted alkyl, phenyl, substituted phenyl, alkoxy, alkylthio, (substituted alkyl)oxy, (substituted alkyl)thio, phenyloxy, phenylthio, (substituted phenyl)oxy or (substituted phenyl)thio.

REFERENCES:
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Campbell, J. Chem. Soc., Chem. Comm., 15:730-731 (1980).
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Grechkin et al., (Chemical Abstracts 58:2418e), (1962).
Grechkin et al., (Chemical Abstracts 63:6939e), (1965).
Grechkin et al., (Chemical Abstracts 66:55295t), (1966).
Gray et al., J. Org. Chem., 44:1768-1771, (1979).
Buchanan, Can. J. Chem., 57:21-26, (1979).
Khamitov et al., Chem. Abs. 66,115768, (1967).

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