3-Acyl-4-ethyl-2-oxazolones and oxazolidinones

Details 3-Acyl-4-ethyl-2-oxazolones and oxazolidinones 3-Acyl-4-ethyl-2-oxazolones and oxazolidinones

1977-04-12

1979-04-17

Rush, Raymond V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260307A, 260558R, 260561R, 260584R, 560106, 560113, 560250, 560253, C07D26326, C07D26338

Patent

active

041500300

ABSTRACT:
This invention relates to the preparation of optically active d-2-aminobutanol by catalytic asymmetric reduction of appropriate dehydro precursors to produce selectively the desired isomer. The same substrates can also be used to prepare the dl-mixture using optically inactive catalysts. The novel substituted-4-ethyl-4-oxazolin-2-one and substituted-4-ethyl-2-oxazolidinone compounds of this invention are useful as intermediates in the production of the antituberculosis drug ethambutol (Myambutol.RTM.).

REFERENCES:
palomo Coll -- C.A. 81, 152210d (1974) -- Abstract of German Offen, 2,408,171.
Elderfield -- "Heterocyclic Compounds" -- vol. 5 -- Wiley & Sons, Inc. -- (1975) -- pp. 400-401.

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