3,9-disubstituted-spiro(5.5)undecanes active on the cardiovascul

Details 3,9-disubstituted-spiro(5.5)undecanes active on the cardiovascul 3,9-disubstituted-spiro(5.5)undecanes active on the cardiovascul

1993-06-28

1995-08-22

Chang, Ceila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514255, 514278, 514397, 514399, 514401, 514438, 514444, 514462, 514632, 514634, 546 15, 5483007, 548407, 549 74, 549 75, 549330, 564227, A61K 31415, C07D40508, C07D40512

Patent

active

054440823

ABSTRACT:
3,9-disubstituted-spiro[5.5]undecanes and ##STR1## wherein, R, Y, A, B and n are defined in the specification, pharmaceutical compositions containing same for the treatment of cardiovascular disorders, such as heart failure and hypertension, are disclosed.

REFERENCES:
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patent: 4963557 (1990-10-01), Dadger
patent: 5234922 (1993-08-01), Welsh
Hamer et al "Drugs for heart disease" Chapman & Hall Publisher, pp. 383-385 (1979).
Berger "Medicinal Chemistry" Interscience Publisher, pp. 565-571, 579-581, 600-601 (1960).
Brown, L. & Erdmann, E., "Comparison of the Affinity of Human, Beef and Cat Heart (Na.sup.+ +K.sup.+)-ATPase for for Different Digitalis Derivatives", Arzneim-Forsh., 1984, 34 (II), 1314.
Jorgensen, Peter Leth, "Purification adn Characterization of (Na.sup.+ -K.sup.+)-ATPase III. Purification from the Outer Medulla of Mammalian Kidney After Selective Removal of Membrane Components by Sodium Dodecylsulpate", Biochimica et Biophysica Acta, (1974), pp. 36-51.
Noel, F, and Godfraind, T., "Heterogeneity of Ouabain Specific Binding Sites and (Na++K-.sub.-- -ATPase Inhibition in Microsomes From Rat Heart", Laboratoire de Pharmacodynamie Generale et de Pharmacologie, Universite Catholique de Louvain., Bruxelles, Belgium, Accepted Jul. 12, 1983.

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