3,6-bridged 9,12-oxolides

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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Details

C536S007200, C536S007300, C536S007400

Reexamination Certificate

active

07407942

ABSTRACT:
The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof:which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

REFERENCES:
patent: 5686587 (1997-11-01), Yang
patent: 6046171 (2000-04-01), Or et al.
patent: 6734292 (2004-05-01), Omura et al.
patent: 6998390 (2006-02-01), Ma et al.
patent: 7229972 (2007-06-01), Or et al.
patent: 2005/0009761 (2005-01-01), Or
patent: 2006/0122128 (2006-06-01), Or et al.
patent: 2006/0142214 (2006-06-01), Or et al.
patent: 2006/0142215 (2006-06-01), Tang et al.
patent: 2006/0148731 (2006-07-01), Tang et al.
patent: WO 00/78773 (2000-12-01), None
patent: WO 03/095466 (2003-11-01), None
patent: WO 03/097659 (2003-11-01), None
Zhenkun, Ma, et al., “Novel Erythromycin Derivatives With Aryl Groups Tethered to the C-6 Position are Potent Protein Synthesis Inhibitors and Active Against Multidrug-Resistant Respiratory Pathogens,”J. Med. Chem.,44:4137-4156 (2001).

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