3-{6-[3-Pyrrolidino-1-(4-tolyl)prop-1-enyl]-2-pyridyl}acrylic ac

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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C07D40106

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active

045018936

ABSTRACT:
This disclosure describes a compound of Formula I ##STR1## (including its pharmaceutically acceptable salts and esters) which has potent antihistamine activity which is substantially free from sedative effects and which has little or no anticholinergic effects.

REFERENCES:
patent: 2567245 (1948-05-01), Sperber
patent: 3862173 (1975-01-01), Carr et al.
patent: 4028352 (1977-06-01), Cavalla et al.
Buzas et al., Journal of Medicinal Chemistry, vol. 23, pp. 149-153, (1980).
Yale, Medicinal and Pharmaceutical Chemistry, vol. I, No. 2, pp. 121 and 131, (1959).

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