3(5)-heteroaryl substituted pyrazoles as p38 kinase inhibitors

Details 3(5)-heteroaryl substituted pyrazoles as p38 kinase inhibitors 3(5)-heteroaryl substituted pyrazoles as p38 kinase inhibitors

1998-05-22

1999-08-03

Higel, Floyd D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142372, 514255, 514318, 514341, 544124, 546193, 5462754, A61K 3144, A61K 31445, A61K 31535, C07D40104, C07D40304, C07D41304

Patent

active

059325763

ABSTRACT:
A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula I ##STR1##

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Sep. 25, 1998 PCT International Search Report (PCT/US98/10807).
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Dannhardt G et al, "Transformations of pyrrolidine enaminones yielding (.omega.-aminopropyl)pyrazoles", Arch. Pharm., vol. 321, No. 1, 1988, pp. 17-19.

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