3, 5 Disubstituted indazole compounds, pharmaceutical...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C546S273400

Reexamination Certificate

active

07008953

ABSTRACT:
3,5 disubstituted indazole compounds that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating CDK dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.

REFERENCES:
patent: 4051145 (1977-09-01), Dupre et al.
patent: 4415569 (1983-11-01), Yasuo et al.
patent: 4978603 (1990-12-01), Inoue et al.
patent: 5208248 (1993-05-01), Baker et al.
patent: 6555539 (2003-04-01), Reich et al.
patent: 0 023 633 (1981-02-01), None
patent: 0 518 805 (1992-02-01), None
patent: 0 494 774 (1992-07-01), None
patent: 0 780 386 (1997-06-01), None
patent: 0 818 442 (1998-01-01), None
patent: 0 904 769 (1999-03-01), None
patent: 2 831 536 (2003-05-01), None
patent: 1 376 600 (1974-12-01), None
patent: 2 345 486 (2000-07-01), None
patent: 59 228248 (1984-12-01), None
patent: 60 4184 (1985-01-01), None
patent: WO 96/20192 (1996-07-01), None
patent: WO 98/02438 (1998-01-01), None
patent: WO 98/43969 (1998-10-01), None
patent: WO 00/38786 (2000-07-01), None
patent: WO 01/53268 (2001-07-01), None
patent: WO 01/85726 (2001-11-01), None
patent: WO 02/10137 (2002-02-01), None
patent: WO 03/004488 (2003-01-01), None
patent: WO 03/035644 (2003-05-01), None
Davies, S., et al., “Specificity and Mechanism of Action of Some Commonly Used Protein Kinase Inhibitors,”Biochemical Journal, 2000, 95-105, vol. 351.
De Lucca, G., et al., “Stereospecific Synthesis, Structure—Activity Relationship, and Oral Bioavailability of Tetrahydrophyrimidin-2-one HIV Protease Inhibitors,”Journal of Medicinal Chemistry, 1999, 135-152, vol. 42, No. 1.
Fujimura, Y., et al., “Synthesis and Pharmacological Activities of 3-Phenylindazole Derivatives,”Yakugaku Zasshi, 1986, 995-1001, vol. 106, No. 11.
Fujimura, Y., et al., “Synthesis and Pharmacological Activities of 2,3-Dihydro-1H-pyrazolo[1,2-a]indazolium Derivatives,”Yakugaku Zasshi, 1986, 1002-1007, vol. 106, No. 11.
Hosoi, T., et al., “Evidence for cdk5 as a Major Activity Phosphorylating Tau Protein in Porcine Brain Extract,”Journal of Biochemistry, 1995, 741-749, vol. 117, No. 4.
Jeffrey, P., et al., “Mechanism of CDK Activation Revealed by the Structure of a CyclinA-CDK2 Complex,”Nature, 1995, 313-320, vol. 376, No. 6538.
Meijer, L., et al., “Chemical Inhibitors of Cyclin-Dependent Kinases,”Methods in Enzymology, 1997, 113-128, vol. 283.
Mosmann, T., “Rapid Colorimetric Assay for Cellular Growth and Survival: Application to Proliferation and Cytotoxicity Assays,”Journal of Immunological Methods, 1983, 55-63, vol. 65.
Rosenblatt, J., et al., “Purification and Crystallization of Human Cyclin-Dependent Kinase 2,”Journal of Molecular Biology, 1993, 1317-1319, vol. 230.
Schang, L. et al., Roscovitine, a Specific Inhibitor of Cellular Cyclin-Dependent Kinases, Inhibits Herpes Simplex Virus DNA Synthesis in the Presen.
Sun, J., et al., “Efficient Synthesis of 5-(Bromomethyl)-and 5-(Aminomethyl)-1-THP-Indazole,”Journal of Organic Chemistry, 1997, 5627-5629, vol. 62, No. 16.
Wentrup, C., et al., “Intramolecular Cyclization of Nitrile Imines. Synthesis of Indazoles, Fluorenes, and Aza Analogues,”Journal of Organic Chemistry, 1978, 2037-2041, vol. 43, No. 10.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

3, 5 Disubstituted indazole compounds, pharmaceutical... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 3, 5 Disubstituted indazole compounds, pharmaceutical..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3, 5 Disubstituted indazole compounds, pharmaceutical... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3597408

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.