3,5-Disubstituted-4'-(9-acridinylamino)-methane-sulfon-m-anisidi

Details 3,5-Disubstituted-4'-(9-acridinylamino)-methane-sulfon-m-anisidi 3,5-Disubstituted-4'-(9-acridinylamino)-methane-sulfon-m-anisidi

1982-06-07

1984-09-18

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424257, C07D21908, A61K 31435

Patent

active

044725825

ABSTRACT:
3,5-Disubstituted-4'-(9-acridinylamino)-methane-sulfon-m-anisidide compounds represented by the general formula ##STR1## in which R.sup.2 and R.sup.3 represent, respectively, --CH.sub.3 and --CONHCH.sub.3, --CH.sub.3 and --CONHCH.sub.2 CONH.sub.2, --Cl and --CONHCH.sub.2 CONH.sub.2, --CONHCH.sub.3 and --CH.sub.3 ; and acid addition salts thereof have unexpectedly high antitumor activity in leukemic animals and low or no direct mutagenicity.

REFERENCES:
patent: 4366318 (1982-12-01), Cain et al.
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Denny et al., J. Med. Chem., vol. 22(12), pp. 1453-1460, (12/79).
Ferguson et al., J. Med. Chem., vol. 23(3), pp. 269-274, (3/80).
Baguley et al., J. Med. Chem., vol. 24(5), pp. 520-525, (5/81).

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