3,5-Diphenyl-1H-1,2,4-triazoles pharmaceutical compositions and

Details 3,5-Diphenyl-1H-1,2,4-triazoles pharmaceutical compositions and 3,5-Diphenyl-1H-1,2,4-triazoles pharmaceutical compositions and

1982-10-15

1985-08-13

Rollins, Alton D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544 63, 514843, 548262, 549308, 549310, 549441, 549442, 560106, A61K 3141, C07D24910, C07D40510

Patent

active

045350906

ABSTRACT:
3,5-diphenyl-1H-1,2,4-triazoles with contragestational activity of the following formula ##STR1## wherein R may be located on one or the other of the two adjacent nitrogen atoms and may represent hydrogen or a group R.sub.5 CO-- wherein R.sub.5 is an aliphatic saturated or unsaturated hydrocarbyl containing from 1 to 20 carbon atoms, R.sub.1, R.sub.2 and R.sub.3, each independently are selected from hydrogen, lower alkyl and lower alkoxy or R.sub.2 and R.sub.3 together may represent a methylenedioxy group, and R.sub.4 is an aliphatic saturated or unsaturated hydrocarbyl group of from 1 to 20 carbons, with the proviso that when R is hydrogen or an R.sub.5 CO-- group wherein R.sub.5 contains 4 or less carbon atoms, R.sub.4 must contain 5 or more carbons.
These compounds have proven to be highly effective in terminating pregnancy in several animal species after a single parenteral injection.

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