3', 5'-Dinucleoside phosphates of 5,6-dichloro-1-.beta.-D-ribofu

Details 3', 5'-Dinucleoside phosphates of 5,6-dichloro-1-.beta.-D-ribofu 3', 5'-Dinucleoside phosphates of 5,6-dichloro-1-.beta.-D-ribofu

1982-08-09

1984-11-13

Siegel, Alan

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435811, 435 68, 424180, C07H 1512, C12P 2100

Patent

active

044827083

ABSTRACT:
A new 3',5'-dinucleoside phosphate, the pharmaceutically acceptable salts thereof and intermediates therefor. The 3',5'-dinucleoside phosphate of 5,6-dichloro-1-.beta.-D-ribofuranosyl-1-benzimidazole and namely 5,6-dichloro-1-.beta.-D-ribofuranosyl-1-benzimidazole-3'-yl-5,6-dichloro-1 -.beta.-D-ribofuranosyl-1-benzimidazole-5'-yl-phosphate possesses potent inducing activity for the cellular synthesis of interferons and in particular .beta.-interferon. The compound is also markedly effective to induce antiviral levels of interferon and possesses significant interferon potentiation properties. The invention also contemplates methods for the preparation of the new compounds and for using the new 3',5'-dinucleoside phosphate.

REFERENCES:
patent: 3764594 (1973-10-01), Roldan et al.
patent: 4378458 (1983-03-01), Gohlke et al.

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