3,5-dihydroxypentanoic acid derivatives useful as antihyperchole

Details 3,5-dihydroxypentanoic acid derivatives useful as antihyperchole 3,5-dihydroxypentanoic acid derivatives useful as antihyperchole

1990-04-30

1992-04-21

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548201, C07D27704, C07D41906

Patent

active

051069920

ABSTRACT:
3,5-Dihydroxypentanoic acid derivatives are provided which are 6-hydroxy-8-(2,2-dimethyl-1-oxybutoxy-2-methyl)-substituted-thiazolidine derivatives and have the structure ##STR1## wherein Z is ##STR2## R.sup.6 is an alkali metal, lower alkyl or H; R.sup.1 and R.sup.2 are the same or different and are H, lower alkyl or aryl; X is S, O, ##STR3## or a single bond; R.sup.7 is lower alkyl; R.sup.3 is lower alkyl or aryl; R.sup.4 and R.sup.5 are the same or different and are H or lower alkyl; and --- represents a single bond or a double bond, and are HMG CoA reductase inhibitors and thus are useful as antihypercholesterolemic agents and in treating atherosclerosis, and also as antifungal agents.
In addition, novel intermediates for use in preparing the above mevinic acid derivatives are also provided.

REFERENCES:
Gyorgydeuk, Croat Chem Acta 60 185 (1987) Chem Abstract 109.37769c.

Affiliated with

Also associated with

Rating

3,5-dihydroxypentanoic acid derivatives useful as antihyperchole does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 3,5-dihydroxypentanoic acid derivatives useful as antihyperchole, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3,5-dihydroxypentanoic acid derivatives useful as antihyperchole will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1587905