3,5-dihydroxyheptanoic acid derivatives

Details 3,5-dihydroxyheptanoic acid derivatives 3,5-dihydroxyheptanoic acid derivatives

1992-09-17

1993-11-30

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546148, 546167, 546196, 546269, 544153, 544149, 548454, 548491, 548525, 5483114, 549 60, 549462, 549467, 549472, 549473, C07D30930, C07D30779, C07D30780

Patent

active

052667073

ABSTRACT:
4-hydroxytetrahydropyran-2-one and 3,5-Dihydroxyheptanoic acid derivatives of formula (I) and formula (II) have an inhibition effect on HMG-CoA reductase, a cholesterol value reduction effect, and an antioxidation function, thus serving as cholesterol reducing agent or lipid reducing agents: ##STR1## wherein R.sup.1 represents hydrogen, a nitro group, or -N(R.sup.4)R.sup.5 in which R.sup.4 and R.sup.5 each represent an alkyl group, an alkenyl group, an aryl group, an aralkyl group; an acyl group, an aroyl group, a carbamoyl group, or a thiocarbamoyl group, and R.sup.4 and R.sup.5 may be combined to form a cyclic amino group; and R.sup.2 and R.sup.3 each represent hydrogen or an alkyl group; and R.sup.6 represents hydrogen, an alkyl group, an alkali metal, or an alkaline earth metal.

REFERENCES:
patent: 5149834 (1992-09-01), Matumoto et al.

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