3,5-dichloro-2,4-dimethoxy-6-(trichloromethyl)pyridine having an

Details 3,5-dichloro-2,4-dimethoxy-6-(trichloromethyl)pyridine having an 3,5-dichloro-2,4-dimethoxy-6-(trichloromethyl)pyridine having an

1986-09-10

1988-01-05

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546296, 546302, C07D21324, C07D21330, A61K 3144

Patent

active

047177268

ABSTRACT:
3,5-Dichloro-2,4-dimethoxy-6-(trichloromethyl)-pyridine, which can be prepared from 2,3,4,5-tetrachloro-6-(trichloromethyl)pyridine and an alkali metal methoxide, is an anticancer agent especially useful for the treatment of leukemias, lymphomas, mammary carcinomas, and ovarian sarcomas.

REFERENCES:
patent: 4190662 (1980-02-01), Fenstermacher et al.
Remers Antineoplastic Agents, pp. 70-76, Wiley-Interscience Pub. 1984.
NIH Publication No. 84-2635, pp. 111, V, 5, 15, 23, 27, 31, "In Vivo Cancer Models" 1976-1982 Pub. NCI Feb. 1984.

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