3,5-diacyl-2,6-dialkyl-4-aryl-1,4-dihydropyridines, their use, a

Details 3,5-diacyl-2,6-dialkyl-4-aryl-1,4-dihydropyridines, their use, a 3,5-diacyl-2,6-dialkyl-4-aryl-1,4-dihydropyridines, their use, a

1986-08-07

1989-02-28

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546271, 546272, 546273, 546274, 546275, 546276, 546278, 546283, 546284, 546139, 546152, 546321, C07D21355, A61K 3144

Patent

active

048086037

ABSTRACT:
Compounds of the formula ##STR1## in which R represents a carbocyclic or heterocyclic aryl radical, R.sub.1 represents lower alkyl, one of the groups R.sub.2 and R.sub.3 represents lower alkyl and the other represents lower alkyl, cyano aor amino, X represents oxygen or the group --NH--, Alk.sub.1 represents lower alkylene or optionally substituted phenyl-lower alkylene, which separates the group X from the nitrogen atom by at least two carbon atoms, R.sub.4 represents hydrogen, lower alkyl or optionally substituted phenyl-lower alkyl, Z represents the group --(C.dbd.O)-- or a single bond, Alk.sub.2 represents lower alkylene which separates the groups Z and Y preferably by from 2 to 4 carbon atoms, Y represents the group --(C.dbd.O)-- and Ar.sub.1 represents a monocyclic, carbocyclic or heterocyclic aryl radical, and salts of such compounds having salt-forming properties, have cardiovascular properties, especially coronary dilatory and anti-hypertensive properties.

REFERENCES:
CA. 97:92145e, 1,4-Dihydropyridine-3,5-Dicarboxylicester Derivatives, p. 758 (1982).
CA. 98:107166j, 1,4-Dihydro-3,5-Pyridinedicarboxylate Esters and Their Salts, p. 589 (1983).
CA. 98:125898d, 1,4-Dihydropyridine-3,5-Dicarboxylic Acid Diesters, p. 622 (1983).
CA. 103:22595v, 1,4-Dihydropyridine Derivatives and Pharmaceutical Compositions Containing Them, p. 579 (1985).
CA. 103:171885s, Calcium Channels: Basic Properties as Revealed by Radioligand Binding Studies, p. 65 (1985).
CA. 103:196015w, Dihydropyridine Compounds and Pharmaceutical Compositions Containing Them, p. 671 (1985).
CA. 104:19517m, Dihydropyridine Derivatives and Their Salts, p. 477 (1986).
CA. 104:88442v, Asymmetrical Diesters of 1,4-Dihydro-2,6-Dimethyl-Pyridine-3,5-Dicarboxylic Acid, p. 648 (1986).
CA. 104:88444x, Dihydropyridine Derivatives, p. 648 (1986).
CA. 104:109644e, 1,4-Dihydropyridine Derivatives and Their Salts, p. 728 (1986).
CA. 104:207171t, Esters of 1,4-Dihydro-2,6-Dimethyl-3-(Alkoxycarbonyl or Alkoxyalkoxycarbonyl)-4-(Substituted Phenylpyridine-5-Carboxylic Acid, p. 745 (1986).

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