3,5-di-tetriary-4-butyl-4-hydroxyphenyloxy- or tioalkylene N-hyd

Details 3,5-di-tetriary-4-butyl-4-hydroxyphenyloxy- or tioalkylene N-hyd 3,5-di-tetriary-4-butyl-4-hydroxyphenyloxy- or tioalkylene N-hyd

1991-05-24

1995-08-15

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Hydroxamic acids, chalcogen analogs or salts thereof

564 28, C07C33512

Patent

active

054421110

ABSTRACT:
3,5-Di-tertiary-butyl-4-hydroxyphenyloxy- or thioalkylene N-hydroxyamides, N-hydroxythioamides, N-hydroxyureas, and N-hydroxythioureas, and pharmaceutically acceptable base salts thereof, pharmaceutical compositions thereof, and methods of manufacture thereof are described. The compounds are said to be selective, potent 5-lipoxygenase inhibitors and useful in treating, for example, inflammatory and allergic conditions.

REFERENCES:
patent: 4755524 (1988-07-01), Mueller et al.
patent: 4857558 (1989-08-01), Mueller
patent: 4873259 (1989-10-01), Summers, Jr. et al.
patent: 4981865 (1991-01-01), Belliotti et al.
patent: 5017604 (1991-05-01), Belliotti et al.
patent: 5036157 (1991-07-01), Kneen et al.
patent: 5075330 (1991-12-01), Belliotti et al.

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