3,5-di-t-butyl-4-hydroxyphenylmethylhydroxylamines and their der

Details 3,5-di-t-butyl-4-hydroxyphenylmethylhydroxylamines and their der 3,5-di-t-butyl-4-hydroxyphenylmethylhydroxylamines and their der

1993-10-12

1995-02-28

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564 17, 564 32, 564 44, 564215, 564218, 564223, 560 24, 544106, 544358, 546184, 549 29, 549429, C07C33500

Patent

active

053939239

ABSTRACT:
The present invention is a novel compound which is a 3,5-di-t-butyl-4-hydroxyphenylmethylhydroxylamine or derivative thereof and a pharmaceutically acceptable acid addition or base salt thereof, pharmaceutical composition and methods of use therefor. The invention compounds are now found to have activity as inhibitors of one or both of cyclooxygenase and 5-lipoxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever, and the like.

REFERENCES:
patent: 5066679 (1991-11-01), Mueller et al.
Derwent Abstract No. 91-181443/25 1991.
Derwent Abstract No. 91-112647/16 1991.

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