3,5-di-t-butyl-4-hydroxylphenylmethylhydroxylamines and their de

Details 3,5-di-t-butyl-4-hydroxylphenylmethylhydroxylamines and their de 3,5-di-t-butyl-4-hydroxylphenylmethylhydroxylamines and their de

1992-01-15

1994-02-22

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

564 28, 564170, 564321, 564 52, 560 8, C07C27100

Patent

active

052888967

ABSTRACT:
The present invention is a novel compound which is a 3,5-di-t-butyl-4-hydroxyphenylmethylhydroxylamine or derivative thereof and a pharmaceutically acceptable acid addition or base salt thereof, pharmaceutical composition and methods of use therefor. The invention compounds are now found to have activity as inhibitors of one or both of cyclooxygenase and 5-lipoxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever, and the like.

REFERENCES:
Derwent Abstract No. 91-112647/JO 3052849 1989.
Derwent Abstract No. 90-181443/25 *JO 310263.
Derwent Abstract No. 91-112647/16*JO 3052849.

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