3 5-bis alkanoyl amino-2 4 6-triiodobenzyl esters

Details 3 5-bis alkanoyl amino-2 4 6-triiodobenzyl esters 3 5-bis alkanoyl amino-2 4 6-triiodobenzyl esters

1995-05-22

1997-02-18

Geist, Gary

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

X-ray contrast imaging agent

560 47, 560103, A61K 4904, C07C22900, C07C 6976

Patent

active

056039166

ABSTRACT:
This invention relates to methods of x-ray diagnostic imaging the blood pool, liver, spleen and/or lymph system of a mammal comprising administering a contrast effective amount of a contrast agent having the structure: ##STR1## wherein: n is 2;
R.sup.1 is H or alkyl containing from 1 to 4 carbon atoms'
R.sup.2 is H, alkyl containing from 1 to 4 carbon atoms, aryl or heteroaryl;
and R.sup.3 is alkyl containing from 1 to 18 carbon atoms.
This invention further relates to novel contrast agents having the above structure wherein R.sup.1 is H and R.sup.2 and R.sup.3 are CH.sub.3 to x-ray contrast compositions comprising such agents, and to method of x-ray diagnostic imaging utilizing such agents.

REFERENCES:
patent: 4022814 (1977-05-01), Newton
patent: 4175544 (1979-11-01), Newton
patent: 4567034 (1986-01-01), Charles et al.
patent: 5318767 (1994-06-01), Liverside et al.
patent: 5488133 (1996-01-01), Singh et al.

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