3(5)-amino-pyrazole derivatives, process for their...

Details 3(5)-amino-pyrazole derivatives, process for their... 3(5)-amino-pyrazole derivatives, process for their...

2006-04-25

2006-04-25

Saeed, Kamal A. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S372500, C548S372100, C548S248000, C548S364400, C548S364700, C548S365700, C548S372100, C544S355000, C544S140000, C544S371000, C546S275400, C546S211000

Reexamination Certificate

active

07034049

ABSTRACT:
Compounds which are 3-amino-pyrazole derivatives represented by formula (I) wherein R is C3–C6cycloalkyl group optionally substituted by a straight or branched C1–C6alkyl or arylalkyl group; R1is a straight or branched C1–C6alkyl, C2–C4alkenyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, arylalkyl, arylcarbonyl, aryloxyalkyl or arylalkenyl group, each of which may be optionally further substituted as indicated in the description; or a pharmaceutically acceptable salt thereof. The compounds are useful for the treatment of cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases or neurodegenerative diseases.

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Pevarello P. et al., “3-Aminopyrazole Inhibitors of CDK2/Cyclin A as Antitumor Agents.1. Lead Finding”, J. Med. Chem. 47:3367-3380 (2004).
Brinkmeyer et al.: “Dimerization of Pyrazole-5-hydroxypyrrolidinones to tetrazocines” Chemical Abstracts, vol. 112, No. 23, abstract No. 216898c Jun. 4, 1990.

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