3,5,7-Trisubstituted pyrazolo[1,5-a]pyrimidines

Details 3,5,7-Trisubstituted pyrazolo[1,5-a]pyrimidines 3,5,7-Trisubstituted pyrazolo[1,5-a]pyrimidines

1976-01-28

1978-06-06

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

424251, C07D48704, A61K 31415

Patent

active

040936171

ABSTRACT:
3,5,7-Trisubstituted pyrazolo[1,5-a]pyrimidines are disclosed of the general formula ##STR1## wherein R.sub.1 is CF.sub.3 or C.sub.1 -C.sub.9 alkyl; R.sub.2 is CF.sub.3 or C.sub.1 -C.sub.9 alkyl; and R.sub.3 is halogen. Such compounds are useful as inhibitors of 3',5'-cyclic AMP phosphodiesterase enzyme.

REFERENCES:
patent: 3920652 (1975-11-01), Springer et al.
patent: 3925385 (1975-12-01), O'Brien et al.
"Chemical Abstracts", vol. 62, 1965, col. 14609h.
"Chemical Abstracts", vol. 64, 1966, col. 2102f.
"Chemical Abstracts", vol. 58, 1963, col. 13949c.
"Chemical Abstracts", vol. 76, 1972, col. 85779c.
Reimlinger, et al., Chem. Ber., vol. 103, 1970, pp. 3252-3254.
Yale, J. Med. and Pharm. Chem., vol. 1, No. 2, (1959), pp. 121-133.

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