3,4-substituted pyrazoles for the treatment of inflammation

Details 3,4-substituted pyrazoles for the treatment of inflammation 3,4-substituted pyrazoles for the treatment of inflammation

1996-09-25

1998-05-26

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5483741, 5483751, C07D23114, A61K 31415

Patent

active

057565309

ABSTRACT:
A class of pyrazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: ##STR1## wherein R.sup.1 is selected from hydrido, alkyl, alkenyl, aralkyl, alkynyl, cyanoalkyl, carboxyalkyl, aminocarbonylalkyl, arylaminocarbonylalkyl, heterocyclicalkyl, and alkoxycarbonylalkyl; wherein R.sup.3 is aryl substituted at a substitutable position with halo; wherein R.sup.4 is selected from hydrido and haloalkyl; and wherein R.sup.5 is selected from alkyl and amino; or a pharmaceutically-acceptable salt or prodrug thereof.

REFERENCES:
patent: 5434178 (1995-07-01), Talley et al.

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