3,4-substituted pyrazoles for the treatment of inflammation

Details 3,4-substituted pyrazoles for the treatment of inflammation 3,4-substituted pyrazoles for the treatment of inflammation

1994-07-21

1996-01-23

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5483731, 5483741, 5483751, 5483761, A61K 31415, C07D23112

Patent

active

054865344

ABSTRACT:
A class of pyrazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: ##STR1## wherein R.sup.1 is selected from hydrido, alkyl, alkenyl, aralkyl, alkynyl, cyanoalkyl, carboxyalkyl, aminocarbonylalkyl, arylaminocarbonylalkyl, heterocyclicalkyl, and alkoxycarbonylalkyl; wherein R.sup.3 is aryl substituted at a substitutable position with halo; wherein R.sup.4 is selected from hydrido and haloalkyl; and wherein R.sup.5 is selected from alkyl and amino; or a pharmaceutically-acceptable salt or prodrug thereof.

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T. Hla and K. Nielson, Proc. Natl. Acad. Sci, USA, 89, 7384 (1992).
J. Masferrer, et al, Proc. Natl. Acad. Sci, USA, 89, 3917 (1992).
E. Meade et al, J. Biol. Chem., 268, 6610 (1993).
N. Futaki et al, Prostaglandins, 47, 55 (1994).

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