3',4'-Episulfido kanamycin B compounds

Details 3',4'-Episulfido kanamycin B compounds 3',4'-Episulfido kanamycin B compounds

1978-02-23

1980-03-25

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, 536 17R, C07H 1522

Patent

active

041951700

ABSTRACT:
New routes are provided for the synthesis of 3',4'-dideoxykanamycin B which is effective in inhibiting kanamycin-resistant organisms from kanamycin B through new intermediate, of which a fundamental process comprises a new reaction of a 3',4'-epoxy derivative of amino- and hydroxyl-protected kanamycin B with a xanthate to form a corresponding 3',4'-dideoxy-3'-eno derivative followed by removal of the amino- and hydroxyl-protecting groups thereof and by hydrogenation of the resulting 3',4'-dideoxy-3'-eno-kanamycin B. A 3',4'-episulfide derivative corresponding to the 3',4'-epoxy derivative which is formed as second product in the reaction of 3',4'-epoxy derivative with xanthate is also used as intermediate for the preparation of 3',4'-dideoxykanamycin B.

REFERENCES:
patent: Re28647 (1975-12-01), Umezawa et al.
patent: 4060682 (1977-11-01), Umezawa et al.

Affiliated with

Also associated with

Rating

3',4'-Episulfido kanamycin B compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 3',4'-Episulfido kanamycin B compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3',4'-Episulfido kanamycin B compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1402507