(3,4-disubstituted)propanoic carboxylates as S1P (Edg)...

Details (3,4-disubstituted)propanoic carboxylates as S1P (Edg)... (3,4-disubstituted)propanoic carboxylates as S1P (Edg)...

2004-12-13

2009-10-20

Saeed, Kamal A (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S364000, C546S269400, C548S131000

Reexamination Certificate

active

07605171

ABSTRACT:
The present invention encompasses compounds of Formula I:as well as the pharmaceutically acceptable salts thereof. The compounds are S1P1/Edg1 receptor agonists and thus have immunosuppressive, anti-inflammatory and hemostatic activities by modulating leukocyte trafficking, sequestering lymphocytes in secondary lymphoid tissues, and enhancing vascular integrity. The invention is also directed to pharmaceutical compositions containing such compounds and methods of treatment or prevention.

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patent: WO 2004/058149 (2004-04-01), None
patent: WO 2004/103279 (2004-12-01), None

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