3,4-disubstituted benzamidines and benzylamines, and...

Details 3,4-disubstituted benzamidines and benzylamines, and... 3,4-disubstituted benzamidines and benzylamines, and...

2007-07-24

2007-07-24

Saeed, Kamal A. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

C514S539000, C560S027000, C560S043000, C562S452000, C562S455000

Reexamination Certificate

active

10858364

ABSTRACT:
The present invention relates generally to compounds that inhibit serine proteases. In particular it is directed to novel 3,4-disubstituted benzamidines and benzylamines, or a stereoisomer or pharmaceutically acceptable salt form thereof, which are useful as selective inhibitors of serine protease enzymes of the coagulation cascade; for example thrombin, factor Xa, factor XIa, factor IXa, and/or factor VIIa. In particular, it relates to compounds that are factor VIIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.

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