3,4-disubstituted-4,5-dihydro-1H-pyrazoles and a method of prepa

Details 3,4-disubstituted-4,5-dihydro-1H-pyrazoles and a method of prepa 3,4-disubstituted-4,5-dihydro-1H-pyrazoles and a method of prepa

1992-08-17

1994-06-28

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544238, 544371, 544315, 544319, 544316, 544318, 544326, 544328, 544327, 544331, 546167, 546152, 546153, 546156, 546279, 5483641, 548127, 548128, 548129, 548131, 548132, 548133, 548134, 548135, 548137, 548143, 548144, 548182, 548186, 548187, 548189, 548190, 548193, 548194, 548195, 548198, 548200, 548201, 548202, 548203, 548204, 548205, 548206, 548213, 548214, 548225, 548228, 548229, 548233, 548235, 548236, 548240, 548243, 548245, 548246, 548247, 548248, C07D40104, C07D40304, C07D41304, C07D41704

Patent

active

053248376

ABSTRACT:
3,4-Diaryl-4,5-dihydro-1H-pyrazole compounds having a selected 5- or 6-membered aromatic heterocyclic moiety in the 4-position and an optionally substituted phenyl moiety in the 3-position, such as 4,5-dihydro-3-(4-fluorophenyl)-4-(5-trifluoromethyl-2-pyridinyl)-1H-pyrazo le were prepared as intermediates in the preparation of insecticidal 3,4,N-triaryl-4,5-dihydro-1H-pyrazole-1-carboxamide compounds. The 3,4-diaryl-4,5-dihydro-1H-pyrazole compounds can be prepared from appropriate 1,2-diarylethanone compounds by successive treatments with N,N,N',N'-tetramethyldiaminomethane in dichloromethane in the presence of acetic anhydride (to form a Mannich adduct) and hydrazine in the presence of a catalytic amount of trifluoroacetic acid.

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