3,4-disubstituted 1H-pyrazole compounds and their use as...

Details 3,4-disubstituted 1H-pyrazole compounds and their use as... 3,4-disubstituted 1H-pyrazole compounds and their use as...

2007-10-19

2010-06-29

Anderson, Rebecca L (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07745638

ABSTRACT:
The invention provides compounds of the formula (0) or salts or tautomers or N-oxides or solvates thereof for use in the prophylaxis or treatment of disease states and conditions such as cancers mediated by cyclin-dependent kinase and glycogen synthase kinase-3.In formula (0):X is a group R1—A—NR4— or a 5- or 6-membered carbocyclic or heterocyclic ring;A is a bond, SO2, C═O, NRg(C═O) or O(C═O) wherein Rgis hydrogen or C1-4hydrocarbyl optionally substituted by hydroxy or C1-4alkoxy;Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length;R1is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C1-8hydrocarbyl group optionally substituted by one or more substituents selected from halogen (e.g. fluorine), hydroxy, C1-4hydrocarbyloxy, amino, mono- or di-C1-4hydrocarbylamino, and carbocyclic or heterocyclic groups having from 3 to 12 ring members, and wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SO2;R2is hydrogen; halogen; C1-4alkoxy (e.g. methoxy); or a C1-4hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4alkoxy (e.g. methoxy);R3is selected from hydrogen and carbocyclic and heterocyclic groups having from 3 to 12 ring members; andR4is hydrogen or a C1-4hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4alkoxy (e.g. methoxy).

REFERENCES:
patent: 4282361 (1981-08-01), Hecht et al.
patent: 4950668 (1990-08-01), Okada et al.
patent: 5502068 (1996-03-01), Lown et al.
patent: 6020357 (2000-02-01), Pinto et al.
patent: 6066738 (2000-05-01), Dinsmore et al.
patent: 6455559 (2002-09-01), Pevarello et al.
patent: 7385059 (2008-06-01), Berdini et al.
patent: 2002/0091116 (2002-07-01), Zhu et al.
patent: 2004/0087798 (2004-05-01), Yamada
patent: 2004/0116399 (2004-06-01), Zhu et al.
patent: 2004/0214870 (2004-10-01), Xin et al.
patent: 2005/0054850 (2005-03-01), Wu et al.
patent: 2005/0119305 (2005-06-01), Naka et al.
patent: 2008/0139620 (2008-06-01), Wyatt et al.
patent: 2008/0161251 (2008-07-01), Curry et al.
patent: 2008/0161355 (2008-07-01), Curry et al.
patent: 2008/0194562 (2008-08-01), Wyatt et al.
patent: 2008/0200509 (2008-08-01), Berdini et al.
patent: 2008/0306069 (2008-12-01), Wyatt et al.
patent: 2009/0012124 (2009-01-01), Wyatt et al.
patent: 2009/0036435 (2009-02-01), Curry et al.
patent: 2009/0142337 (2009-06-01), Squires et al.
patent: 0289879 (1988-11-01), None
patent: 0492125 (1992-07-01), None
patent: 0538231 (1993-04-01), None
patent: 0947500 (1999-10-01), None
patent: 1348707 (2003-10-01), None
patent: 1642594 (2006-04-01), None
patent: 97/19052 (1997-05-01), None
patent: 97/19062 (1997-05-01), None
patent: 97/36585 (1997-10-01), None
patent: 97/36881 (1997-10-01), None
patent: 97/36897 (1997-10-01), None
patent: 97/48672 (1997-12-01), None
patent: 98/28269 (1998-07-01), None
patent: 9849166 (1998-11-01), None
patent: 9852941 (1998-11-01), None
patent: 98/57937 (1998-12-01), None
patent: 99/32454 (1999-07-01), None
patent: 9932477 (1999-07-01), None
patent: 00/39108 (2000-07-01), None
patent: 00/59902 (2000-10-01), None
patent: 00/62778 (2000-10-01), None
patent: 00/68191 (2000-11-01), None
patent: 00/71516 (2000-11-01), None
patent: 01/02369 (2001-01-01), None
patent: 01/02385 (2001-01-01), None
patent: 01/14331 (2001-03-01), None
patent: 01/19798 (2001-03-01), None
patent: 0119788 (2001-03-01), None
patent: 01/53274 (2001-07-01), None
patent: 01/58869 (2001-08-01), None
patent: 01/64642 (2001-09-01), None
patent: 0164643 (2001-09-01), None
patent: 01/81316 (2001-11-01), None
patent: 01/81345 (2001-11-01), None
patent: 01/98290 (2001-12-01), None
patent: 02/00651 (2002-01-01), None
patent: 02/10146 (2002-02-01), None
patent: 02/18346 (2002-03-01), None
patent: 02/22601 (2002-03-01), None
patent: 02/22603 (2002-03-01), None
patent: 02/22605 (2002-03-01), None
patent: 02/22608 (2002-03-01), None
patent: 02/34721 (2002-05-01), None
patent: 02/051810 (2002-07-01), None
patent: 02/062804 (2002-08-01), None
patent: 02/064586 (2002-08-01), None
patent: 02/070483 (2002-09-01), None
patent: 02074312 (2002-09-01), None
patent: 02074774 (2002-09-01), None
patent: 02/083624 (2002-10-01), None
patent: 02/094791 (2002-11-01), None
patent: 02101007 (2002-12-01), None
patent: 03/011287 (2003-02-01), None
patent: 03/020217 (2003-03-01), None
patent: 03018536 (2003-03-01), None
patent: 03024448 (2003-03-01), None
patent: 03/040147 (2003-05-01), None
patent: 03/048081 (2003-06-01), None
patent: 03/048158 (2003-06-01), None
patent: 03/048158 (2003-06-01), None
patent: 03/068767 (2003-08-01), None
patent: 03/077918 (2003-09-01), None
patent: 03082872 (2003-10-01), None
patent: 2004/000318 (2003-12-01), None
patent: 2004/014864 (2004-02-01), None
patent: 2004/039795 (2004-06-01), None
patent: 2004/060306 (2004-07-01), None
patent: 2004/085385 (2004-10-01), None
patent: 2004/099127 (2004-11-01), None
patent: 2004/099148 (2004-11-01), None
patent: 2005/000309 (2005-01-01), None
patent: 2005058881 (2005-06-01), None
patent: 2006/014290 (2006-02-01), None
patent: 2007/129062 (2007-11-01), None
patent: 2007/129066 (2007-11-01), None
patent: 2008/001101 (2008-01-01), None
patent: 2008/007113 (2008-01-01), None
patent: 2008/007122 (2008-01-01), None
patent: 2008/007123 (2008-01-01), None
patent: 2008/009954 (2008-01-01), None
patent: 2008/044041 (2008-04-01), None
Berdini et al., U.S. Appl. No. 11/875,482; “3,4-Disubstituted 1H-Pyrazole Compounds And Their Use As Cyclin Dependent Kinase And Glycogen Synthase Kinase-3 Modulators”; filed Oct. 19, 2007.
Voskoglou-Nomikos et al., “Clinical Predictive Value of the in Vitro Cell Line, Human Xenograft, and Mouse Allograft Preclinical Cancer Models.” Clinical Cancer Research, vol. 9, pp. 4227-4239, (2003).
Wyatt et al., “Identification of N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.” Journal of Medicinal Chemistry, vol. 51, No. 16, pp. 4986-4999, (2008).
Squires et al., “Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines.” Molecular Cancer Therapeutics: vol. 8(2). pp. 324-332, (2009).
International Search Report and International Preliminary Report on Patentability with Written Opinion for PCT International Application No. PCT/GB2004/003179, (Oct. 2, 2005).
Vippagunta et al.: Crystalline Solids, Advanced Drug Delivery Reviews, 48, 3-26 (2001).
Patani et al.: Chem. Rev. 96, 3147-3176 (1996).

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