3,4-Disubstituted-1,2,5-thiadiazole-1-oxide compounds

Details 3,4-Disubstituted-1,2,5-thiadiazole-1-oxide compounds 3,4-Disubstituted-1,2,5-thiadiazole-1-oxide compounds

1981-06-23

1983-02-15

Rollins, Alton D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548266, 548269, 2602455, 548255, 560137, 260465D, 560148, 564239, 2604654, 424246, 42424851, 42424852, 42424856, 42424857, 42424858, 424250, 424263, 424267, 424270, 544 587, 544 60, 544134, 544367, 546194, 546209, 546284, 546299, 548125, 548127, 548131, 548134, 546300, 548143, 548193, 548201, 548203, 548204, 548205, C07D28510

Patent

active

043742483

ABSTRACT:
Histamine H.sub.2 -antagonists of the formula ##STR1## wherein p is 1 or 2; R.sup.1 is hydroxy, amino, substituted amino or a 5- to 9-membered fully saturated nitrogen-containing heterocyclic ring attached via its nitrogen atom; m is an integer of from 0 to 2; n is an integer of from 2 to 4; Z is sulfur, oxygen or methylene; and A is an optionally substituted phenyl, imidazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, triazolyl, thiadiazolyl, oxadiazolyl, furyl, thienyl or pyridyl ring; and nontoxic pharmaceutically acceptable salts, hydrates, solvates or N-oxides thereof are novel anit-ulcer agents. Intermediates and processes for their preparation are disclosed.

REFERENCES:
patent: 3419573 (1968-12-01), Weinstock et al.
patent: 3564000 (1971-02-01), Weinstock et al.
Wen et al., J. Org. Chem., vol. 40, pp. 2743-2748, (1975).
Weinstock et al. III, J. Org. Chem., vol. 32, pp. 2823-2829, (1967).
Carmack et al., Organic Preparations and Procedures, vol. 1, pp. 255-258, (1969).

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