(3,4-dioxocyclobuten-1-yl)chromene, indene, and dihydronaphthale

Details (3,4-dioxocyclobuten-1-yl)chromene, indene, and dihydronaphthale (3,4-dioxocyclobuten-1-yl)chromene, indene, and dihydronaphthale

1994-06-28

1996-01-09

Kestler, Kimberly J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514255, 514256, 514259, 514266, 514311, 514314, 514336, 514337, 514357, 514375, 514394, 514406, 514414, 514415, 514422, 514427, 514438, 514443, 514444, 514456, 514457, 514461, 514469, 514510, 514522, 514524, 514562, 514563, 514564, 514567, 514603, 514616, 514617, 514618, 514647, 544283, 544333, 544335, 544336, 544405, 544410, 560 6, 560 12, 560 13, 560 18, 560 19, 560 21, 560 22, 560 23, 560 45, 560 47, 560 48, 546167, 546173, 546269, 546329, 546330, 546332, 546346, 549 49, 549 58, 549 60, 549 74, 549 75,

Patent

active

054829429

ABSTRACT:
This invention relates to novel 4-(3,4-dioxocyclobuten-1-yl)chromenes and dihydronaphthalenones and 3-(3,4-dioxocyclobuten-1-yl)indenes and salts thereof having smooth muscle relaxing activity, to their use in the treatment of hypertension as well as for treatment of peripheral vascular disease, congestive heart failure, disorders involving excessive smooth muscle contraction of the urinary tract such as incontinence or of the gastrointestinal tract such as irritable bowel syndrome, asthma, and hair loss and to pharmaceutical compositions containing an invention compound. The present invention discloses compounds represented by the formula (I): ##STR1## wherein: R.sub.1 and R.sub.2, independent from each other, are selected from the following: C.sub.1-6 perfluoroalkoxy, C.sub.1-6 perfluoroalkyl, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, hydroxyl, C.sub.1-6 alkoxycarbonyl, nitro, cyano, halogen, C.sub.1-6 alkylsulfonamido, C.sub.1-6 perfluoroalkylsulfonamido, amino, C.sub.1-6 acylamino, C.sub.1-6 perfluoroacylamino, mono or di-C.sub.1-12 alkylamino, C.sub.1-6 alkylsulfonyl, C.sub.6-10 arylsulfonyl, carboxyl, C.sub.1-12 mono or di-alkylaminocarbonyl, or hydrogen;

REFERENCES:
patent: 5006550 (1991-04-01), Chandraratna
patent: 5071871 (1991-12-01), Blarer et al.
patent: 5134159 (1992-07-01), Chandraratna
patent: 5141939 (1992-08-01), Weissmuller et al.
patent: 5143924 (1992-09-01), Gerecke et al.
patent: 5210234 (1993-05-01), Evans et al.
patent: 5227392 (1993-07-01), Frickel et al.
patent: 5227499 (1993-07-01), McGowan et al.
patent: 5231190 (1993-07-01), McGowan et al.
patent: 5232944 (1993-08-01), Gerecke et al.
patent: 5236935 (1993-08-01), Yoo et al.
patent: 5250547 (1993-10-01), Lockhead et al.
patent: 5278174 (1994-01-01), Erickson et al.
patent: 5298512 (1994-03-01), Eggler et al.
patent: 5393775 (1995-02-01), LeBaut et al.
patent: 5399561 (1995-03-01), Chandrarantna
patent: 5412117 (1995-05-01), Koga et al.
patent: 5414006 (1995-05-01), Rendenbach-Mueller et al.
patent: 5426229 (1995-06-01), Schaus et al.
Liebeskind and Fengl, J. Org. Chem. 55, 5359-5364 (1990).

Affiliated with

Also associated with

Rating

(3,4-dioxocyclobuten-1-yl)chromene, indene, and dihydronaphthale does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with (3,4-dioxocyclobuten-1-yl)chromene, indene, and dihydronaphthale, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and (3,4-dioxocyclobuten-1-yl)chromene, indene, and dihydronaphthale will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1303292