3,4-dihydroquinazoline derivatives as T-type calcium channel...

Details 3,4-dihydroquinazoline derivatives as T-type calcium channel... 3,4-dihydroquinazoline derivatives as T-type calcium channel...

2007-09-18

2007-09-18

Bernhardt, Emily (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C544S283000, C514S266100, C514S266200, C514S266220, C514S252170, C514S234500

Reexamination Certificate

active

11018786

ABSTRACT:
The present invention relates to 3,4-dihydroquinazoline derivatives as T-type calcium channel blockers and a method of preparing the same. The present invention further relates to a composition comprising the same. The composition comprising the 3,4-dihydroquinazoline derivatives of the present invention can be effectively used for preventing and treating angina pectoris, high blood pressure, myocardial disease, pain and epilepsy by blocking the T-type calcium channel.

REFERENCES:
patent: WO 03007953 (2003-01-01), None
patent: WO 03031415 (2003-04-01), None
Takao Saito et al: “A Facile and Efficient Carbodiimide-Mediated Synthesis of Dihydroquinazolines via a Tandem Nucleophilic Addition-Intramalecular Hetero Conjugate Addition Annulation Strategy” Tetrahedron Letters, Elsevier Science Publishers, Amsterdam, NL, vol. 37, No. 2, 1996, pp. 209-212, XP002326650.
Wang F et al: “Solid-Phase Synthesis of 3,4-Dihydroquinazoline” Tetrahedron Letters, Elsevier Science Publishers, Amsterdam, NL, vol. 38, No. 50, (Dec. 15, 1997), pp. 8651-8654, XP004097142.
S. I. Ertel et al: “Mibefradfil (Ro 40-5967): the first selective T-type Ca2+ channel blocker” Expert Opinion on Investigational Drugs, vol. 6, No. 5, 1997, pp. 569-582 XP002332318.
Yong Sup Lee et al: “3,4-Dihydroquinazoline derivatives as novel selective T-type Ca2+ channel blockers” Bioorganic & Medicinal Chemistry Letters, Oxford, GB, vol. 14, 2004, pp. 3379-3384, XP002326652.
Munikumar Reddy Doddareddy et al: “First pharmacophoric hypothesis for T-type calcium channel blockers” Bioorganic & Medicinal Chemistry, vol. 12, 2004, pp. 1605-1611, XP002332319.

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