3,4-Dihydropyrrolo-[1,2-a]-pyrazine and method of preparing same

Details 3,4-Dihydropyrrolo-[1,2-a]-pyrazine and method of preparing same 3,4-Dihydropyrrolo-[1,2-a]-pyrazine and method of preparing same

1978-03-30

1980-08-05

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544 31, C07D27930

Patent

active

042163218

ABSTRACT:
The novel compound according to the present invention, viz. 3,4-dihydropyrrolo-[1,2-a]-pyrazine has the formula: ##STR1## The method of preparing this compound comprises reacting dialkylacetals or dioxalane of a 2,5-dialkoxytetrahydrofurfurol with ethylenediamine in a medium of lower aliphatic acids at a temperature within the range of from 100.degree. to 150.degree. C., followed by isolation of the desired product.
The novel compound according to the present invention, viz. 3,4-dihydropyrrolo-[1,2-a]-pyrazine, owing to a simple method for producing same, simplifies the process of manufacture of physiologically active compounds employed in neuroleptic or coronary dilating preparations, wherein it may be used as the starting material.

REFERENCES:
patent: 3531485 (1970-09-01), Freed
patent: 3998820 (1976-12-01), Likhosherstov et al.
patent: 4044015 (1977-08-01), Kuhla
Rayevskii, et al., "Pharm. Chem. Jour.", (USSR), vol. 10, 1976, pp. 55-58.
Freed, et al., "J. Org. Chem.", vol. 25, 1960, pp. 2108-2113.
Nazarova, "Pharm. Chem. Journ.", (USSR), vol. 10 (1), 1976, pp. 88-92.
Likhosherstov, et al., "Zhurnal Organicheskoi Khim", vol. VI, (N8), 1970, pp. 1729-1734.
Ponomarev, et al., "Poklady Akademii Nauk", (USSR), vol. 148, (N4), 1963, pp. 860-862.

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