3,4-Dihydrocarbostyril derivatives

Details 3,4-Dihydrocarbostyril derivatives 3,4-Dihydrocarbostyril derivatives

1975-11-10

1978-02-07

Rollins, Alton D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260286R, 260289K, 424258, C07D21522, C07D21526, A61K 3147

Patent

active

040726835

ABSTRACT:
Novel (3'-alkylamino-2'-hydroxy)propoxy-3,4-dihydrocarbostyril derivatives having .beta.-adrenergic nerves blocking activity and hypotensive activity and useful as a remedy for angina pectoris, irregular pulse and hypertension, etc., represented by the formula, ##STR1## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.4 alkyl or aralkyl and R.sub.2 is C.sub.1 -C.sub.4 alkyl, are prepared by reacting a 3,4-dihydrocarbostyril derivative represented by the formula, ##STR2## wherein R.sub.1 is C.sub.1 -C.sub.4 alkyl or aralkyl, with an epihalogenohydrin represented by the formula, ##STR3## wherein X is halogen, reacting the resulting product with an alkylamine represented by the formula,

REFERENCES:
patent: 3340266 (1967-09-01), Howe et al.
patent: 3910924 (1975-10-01), Tamura et al.
patent: 3919239 (1975-11-01), Nakagawa et al.
patent: 3953456 (1976-04-01), Nakagawa et al.

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