3,4-Dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-3-carboxylic aci

Details 3,4-Dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-3-carboxylic aci 3,4-Dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-3-carboxylic aci

1976-06-10

1978-07-11

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

424246, C07D27902

Patent

active

041003470

ABSTRACT:
Process for production of 3,4-dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-3-carboxylic acid-1,1-dioxide by hydrolysis, in the presence of hydroxide ions, of an alkyl or aralkyl ester thereof followed by precipitation of the acid at pH below 6.0 and its use as an intermediate for the production of N-(2-pyridyl)-3,4-dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-3-carboxamid e-1,1-dioxide and the analogous N-(2-thiazolyl)-compound, effective antiinflammatory agents.

REFERENCES:
patent: 3492298 (1970-01-01), Rasmussen
patent: 3591584 (1971-07-01), Lombardino
patent: 3808205 (1974-04-01), Sircar et al.
patent: 3892740 (1975-07-01), Lombardino
Lombardino et al., J. Heterocyclic Chem., vol. 13, pp. 333-335 (1976).

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