3'4'-dideoxy-3'-fluorokanamycin B and production thereof

Details 3'4'-dideoxy-3'-fluorokanamycin B and production thereof 3'4'-dideoxy-3'-fluorokanamycin B and production thereof

1986-08-22

1989-07-04

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 137, 536 138, A61K 3170, C07H 1522

Patent

active

048450820

ABSTRACT:
New compound, 3',4'-dideoxy-3'-fluorokanamycin B is now provided, which is useful as antibacterial agent.
3',4'-Dideoxy-3'-fluorokanamycin B is prepared by a process comprising halogenating an N,O-protected derivative of 3'-deoxy-3'-fluoro-4'-O-sulfonylkanamycin B with a metal halide, reducing the resulting 4'- halogenated 3'-deoxy-3'-fluorokanamycin B derivative to convert its 4'-halo group into a hydrogen atom, and thereby to produce an N,O-protected derivative of 3',4'-dideoxy-3'-fluorokanamycin B, and removing the remaining amino-protecting groups and the remaining hydroxyl-protecting groups from the reduction product by conventional deprotecting methods.

REFERENCES:
patent: 4349666 (1982-09-01), Umezawa et al.
patent: 4634688 (1987-01-01), Umezawa et al.
patent: 4661474 (1987-04-01), Umezawa et al.

Affiliated with

Also associated with

Rating

3'4'-dideoxy-3'-fluorokanamycin B and production thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 3'4'-dideoxy-3'-fluorokanamycin B and production thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3'4'-dideoxy-3'-fluorokanamycin B and production thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-852510