3,4-Diarylisoxazol-5-acetic acids and process for making same

Details 3,4-Diarylisoxazol-5-acetic acids and process for making same 3,4-Diarylisoxazol-5-acetic acids and process for making same

1980-09-23

1982-04-27

Sutto, Anton H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424272, C07D26108, A61K 3142

Patent

active

043272223

ABSTRACT:
3,4-Diarylisoxazol-5-acetic acids of the formula ##STR1## in which Ar.sup.1 and Ar.sup.2 are the same or different and are selected from phenyl and naphthyl, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are the same or different and are selected from hydrogen, halogen, trifluoromethyl, lower alkyl, and lower alkoxy, and R.sup.5 is selected from hydrogen, lower alkyl, and lower alkoxy. The compounds have anti-inflammatory, analgesic, and anti-pyretic activities and a low order of toxicity, and methods for their preparation and use are also disclosed.

REFERENCES:
patent: 3891635 (1975-06-01), Henniger
patent: 4010264 (1977-03-01), Henniger
Micetich, Can. J. Chem. 48, 2006 (1970).
Chem. Abs. 70, 20054u (1969).
Chem. Abs. 77, 48483b (1972).
Chem. Abs. 80, 108511h and 108513k.
Beam et al., J. Org. Chem. 35, 1806 (1970).
Chemistry of Carbon Compounds, E. H. Rodd, Ed., vol. III, 1168-1171, New York 1956.
Winter et al., Proc. Soc. Exp. Biol. Med. 111, 544 (1962).
Winder et al., J. Pharmacol. Exp. Therap. 138, 405 (1962).
Siegmund et al., Proc. Soc. Exp. Biol. Med. 95, 729 (1957).
Sofia et al., J. Pharm. Sci. 64, 1321 (1975).
Litchfield and Wilcoxon, J. Pharmacol. Exp. Therap. 96, 99 (1949).

Affiliated with

Also associated with

Rating

3,4-Diarylisoxazol-5-acetic acids and process for making same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 3,4-Diarylisoxazol-5-acetic acids and process for making same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3,4-Diarylisoxazol-5-acetic acids and process for making same will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2198831