3,4-diaryl-2-hydroxy-2,5-dihydrofurans as prodrugs to COX-2 inhi

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514471, 514472, 514473, 549222, 549331, 549476, 549479, 549480, C07D30732, A61K 3134

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056985843

ABSTRACT:
The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.

REFERENCES:
patent: 5344991 (1994-09-01), Reitz et al.
patent: 5393790 (1995-02-01), Reitz et al.
Taniguchi, et al., Chem. Pharm. Bull. 42(4) pp. 896-902 (1994).
Li., et al., J. of Med. Chem., vol. 38, No. 22, pp. 4570-4578 (1995).

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