3,4-(Bis-substituted)-1,2,5-oxdiazole 2-oxides, their use and ph

Details 3,4-(Bis-substituted)-1,2,5-oxdiazole 2-oxides, their use and ph 3,4-(Bis-substituted)-1,2,5-oxdiazole 2-oxides, their use and ph

1981-12-18

1982-10-26

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

42424855, 42424857, 424250, 424267, 424272, 544 82, 544138, 544357, 544367, 546187, 546209, 2602455, 548125, A61K 31535, A61K 3142, C07D41314

Patent

active

043561780

ABSTRACT:
Pharmacologically-valuable 3,4-(bis-substituted)-1,2,5-oxdiazole 2-oxides of formula I ##STR1## [wherein R denotes --NHR.sup.1, --NR.sup.2 R.sup.3, --NHR.sup.4 OR.sup.2, --NHR.sup.5 COR.sup.6 or ##STR2## R.sup.1 denotes alkyl having from 1 to 6 C atoms or cycloalkyl having 4 to 7 ring C atoms, R.sup.2 and R.sup.3 denote alkyl having from 1 to 4 C atoms, R.sup.4 denotes an alkylene radical of the formula --C.sub.n H.sub.2n --(wherein n denotes 2, 3 or 4), R.sup.5 denotes an alkylene radical of the formula --C.sub.m H.sub.2m -- (wherein m denotes 1, 2 or 3), R.sup.6 denotes --OR.sup.2, --NHR.sup.1, --NR.sup.2 R.sup.3 or --NH.sub.2, X denotes --(CH.sub.2).sub.p --, --(CH.sub.2).sub.2 --O--(CH.sub.2).sub.2 -- or ##STR3## and p is 4, 5 of 6] and their pharmacologically-acceptable acid-addition compounds are prepared by elimination of hydrogen chloride from a hydroxamoyl chloride of the formula

REFERENCES:
patent: 4089867 (1978-05-01), Duranleau et al.
Schoenafinger et al., Chemical Abstracts, vol. 96, (1981), No. 40909s.
Grundman et al., Chemical Abstracts, vol. 88, (1975), No. 50732c.

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