3-[(4-Aroyl) phenoxy (or phenylthio)]-cyclopentanecarboxylic aci

Details 3-[(4-Aroyl) phenoxy (or phenylthio)]-cyclopentanecarboxylic aci 3-[(4-Aroyl) phenoxy (or phenylthio)]-cyclopentanecarboxylic aci

1986-06-21

1990-04-10

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514568, 548253, 562460, C07D25704, A61K 3141, A61K 3112, C07C 4923

Patent

active

049161474

ABSTRACT:
Novel compounds of the general formula: ##STR1## [wherein X represents an oxygen atom or sulfur atom, R.sup.1, R.sup.2 and R.sup.3 represent a hydrogen atom, a halogen atom or an alkyl group of from 1 to 4 carbon atom(s) independently or a formula: R.sup.3' ##STR2## (wherein R.sup.3' represents a hydrogen atom or an alkyl group of from 1 to 4 carbon(s))
in place of a formula: ##STR3## R.sup.4 represents a general formula: ##STR4## or --N(R.sup.9).sub.2 (in which W represents an oxygen atom or sulfur atom, R.sup.6, R.sup.7 and R.sup.8 represent a hydrogen atom, a halogen atom, a nitro group, an alkyl group of from 1 to 4 carbon atom(s), a hydroxy group or an alkoxy group of from 1 to 4 carbon atom(s) independently, each of R.sup.9 represents a hydrogen atom, an alkyl group of from 1 to 4 carbon atom(s) or a phenyl group and Y represents a single bond or an alkylene group or an alkenylene group of from 1 to 4 carbon atom(s).), and R.sup.5 represents a 5-tetrazolyl group or a general formula: --COOR.sup.10 (in which R.sup.10 represents a hydrogen atom or an alkyl group of from 1 to 4 carbon atom(s))]
and non-toxic salts possess inhibitory effect on cerebral edema.

REFERENCES:
patent: 3398188 (1968-08-01), Schultz
patent: 4058559 (1977-11-01), Jones et al.

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