3-(4-Acylaminopiperazin-1-yl alkyl)indoles, precursors and proce

Details 3-(4-Acylaminopiperazin-1-yl alkyl)indoles, precursors and proce 3-(4-Acylaminopiperazin-1-yl alkyl)indoles, precursors and proce

1974-05-31

1976-12-14

Coughlan, Jr., Paul M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424250, C07D29504

Patent

active

039975398

ABSTRACT:
New 3-(4-acylaminopiperazin-1-ylalkyl)indole compounds, and their immediate precursors possessing antihypertensive and tranquilizing properties, their physiologically acceptable salts and a process for the preparation thereof are described; said compounds are of the general formula: ##STR1## wherein X represents hydrogen or hydroxy, n can vary from 0-1, R.sub.1 and R.sub.2 each represents hydrogen or alkoxy of 1-2 carbon atoms; R.sub.3 represents hydrogen or alkyl of 1-3 carbon atoms and Z represents hydrogen or ##STR2## and R.sub.4 is selected from a member of the group consisting of alkyl of 1-4 carbon atoms, benzhydryl, cycloalkyl of 6-10 carbon atoms; bridged cycloalkyl of 6-10 carbon atoms, phenyl, mono, di or tri substituted phenyl, and heterocyclic moieties such as pyridyl, furyl, pyrrolyl, thienyl, pyrazinyl.

REFERENCES:
patent: 2663706 (1953-12-01), Conroy
patent: 2663707 (1953-12-01), Conroy et al.
patent: 3188313 (1965-06-01), Archer
patent: 3297689 (1967-01-01), Cusic et al.

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