[3,4-a:3,4-c]carbazole compounds

Details [3,4-a:3,4-c]carbazole compounds [3,4-a:3,4-c]carbazole compounds

2006-12-19

2006-12-19

McKane, Joseph K. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S410000, C546S048000, C548S418000

Reexamination Certificate

active

07151108

ABSTRACT:
A compound selected from those of formula (I):wherein:W1represents, together with carbon to which it is bonded, phenyl, pyridyl,Z represents a group of formula U—V as defined in the description,Q1represents oxygen, NR2as defined in the description,Q2represents oxygen, NR′2as defined in the description,X1, X2, X′1and X′2each represents hydrogen, hydroxy, alkoxy, mercapto or alkylthio,Y1, Y2, Y′1and Y′2each represents hydrogen,or X1and Y1, X2and Y2, X′1and Y′1, X′2and Y′2with carbon carrying them, together form carbonyl or thiocarbonyl,R1is as defined in the description,its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.

REFERENCES:
Bergman et al., Acid-induced dimerization of 3-(1H-indol-3-yl)maleimides. Formation of cyclopentindole derivatives., J. Chem. Soc., Perkin Trans. 1, 2000, 2615-2621.
Cancer and Metastasis Reviews (1998), 17(1), 91-106.
Science (1999), vol. 286, 531-537.

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