3- [4- (2- Phenyl-Indole-1-ylmethyl) Phenyl]- Acrylamides as est

Details 3- [4- (2- Phenyl-Indole-1-ylmethyl) Phenyl]- Acrylamides as est 3- [4- (2- Phenyl-Indole-1-ylmethyl) Phenyl]- Acrylamides as est

1997-04-14

1999-11-16

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514613, 514617, 514619, 548490, 548491, 548503, 548511, 564163, 564166, 564180, A61K 31165, C07D20904, C07D20918, C07D23310

Patent

active

059859105

ABSTRACT:
The present invention relates to new 3-[4-(2-Phenyl-Indole-1-ylmethyl)-Phenyl]-Acrylamide compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treatment utilizing these compounds, the compounds having the following general structure. ##STR1##

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patent: 5496844 (1996-03-01), Inai et al.
von Angerer et al., Amer. Chem. Soc., pp. 2635-2640, 1990.
von Angerer et al., Amer. Chem. Soc., pp. 132-136, 1986.
Biberger et al., J. Steroid Biochem. Molec. Biol., vol. 58, No. 1, pp. 31-43, 1996.
Henderson et al., Ann. N.Y. Aca. Sci., pp. 176, 177, 189, 1995.
Oparil "Hypertension in postmenopausal Woman:Pathology and Management" EMBASE 95:283951, 1995.
von Angerer et al., J. Med. Chem. vol. 27, pp. 1439-1447, 1984.
Biberger "2-Phenylindoles with Sulfer Containing Side Chains", CA 125:316191, 1996.

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