3-(3H-Pyrazol-3-one)-2-(disubstituted aminomethyl)indoles and ph

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...

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424274, 548364, 2603191, 26032613F, 26032613B, 26032614R, 26032615, A61K 31415, C07D40306

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active

041537114

ABSTRACT:
.beta.-[2-[(DIALKYLAMINO)METHYL]-1H-indol-3-yl]-.alpha.,.alpha.-diphenylpro pionitriles and 4-[[2-[(dialkylamino)methyl]-1H-indol-3-yl]methyl]-2,4-dihydro-5-lower alkyl-2-phenyl-3H-pyrazol-3-ones and acid addition salts thereof which are useful pharmacological agents, especially as central nervous system depressants, are disclosed. The compounds can be produced by reacting an anion of an acetonitrile or a pyrazol-3-one with the appropriate quatenary salt of 2-alkyl-1,2,3,4-tetrahydropyrrolo[3,4-b]indole.

REFERENCES:
patent: 3247201 (1966-04-01), De Marle et al.
patent: 3637748 (1972-01-01), Psaar et al.
patent: 3931229 (1976-01-01), Zinnes et al.
patent: 3931230 (1976-01-01), Zinnes et al.

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