3,3A,6,6A-Tetrahydrofuro[3,4-b]furan derivatives and anti-ulcer

Details 3,3A,6,6A-Tetrahydrofuro[3,4-b]furan derivatives and anti-ulcer 3,3A,6,6A-Tetrahydrofuro[3,4-b]furan derivatives and anti-ulcer

1975-09-11

1977-06-28

Jaisle, Cecilia M. S.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Synthetic or structurally-modified peptidoglycan or...

2603436, 260485R, 260592, C07D49304

Patent

active

040326519

ABSTRACT:
Pharmaceutical compositions containing 3,3a,6,6a-tetrahydrofuro[3,4-b]furan derivatives including canadensolide and 3-epi-dihydrocanadensolide. Novel 3,3a,6,6a-tetrahydrofuro[3,4-b]furan derivatives bearing a variety of substituents in the 3- and 6-positions selected from alkyl, phenyl, alkoxycarbonyl, methylene, benzylthiomethyl and optionally substituted phenylthiomethyl. The compositions and novel compounds show anti-ulcer activity and are useful in the treatment of gastric or duodenal ulcers.

REFERENCES:
patent: 3930014 (1975-12-01), Aldridge et al.
Yoshikoshi, Japan Kokai 73-40, 796, Jan. 15, 1973 (cited as C.A. 79:66338d).
Zalinyan, et al., Arm. Khim. Zh. 1973, 26(12) 1015-1019 (cited as C.A. 81:3701n).
Mukaiyama, et al., Bull. Soc. Chem. Jap. 1971, 44(1), 161-166 (cited as C.A. 74:76349u).
Yoshikoshi (II), Japan Kokai 73-40, 797, Jan. 15, 1973 (cited as C.A. 79:66337d).

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