3',3-N-bis-substituted macrolide LHRH antagonists

Details 3',3-N-bis-substituted macrolide LHRH antagonists 3',3-N-bis-substituted macrolide LHRH antagonists

1998-03-27

1999-10-26

Peselev, Elli

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 72, 536 74, 536 185, A61K 3170, C07H 100, C07H 1708

Patent

active

059728981

ABSTRACT:
Disclosed are 3',3'-N-bisdesmethyl-3',3'-N-bis-substituted-6-O-methyl-11-deoxy-11,12-cyc lic carbamate erythromycin A derivatives which are antagonists of lutenizing hormone-releasing hormone (LHRH). Also disclosed are pharmaceutical compositions comprising the compounds, to methods of using the compounds and to the process of making the same.

REFERENCES:
patent: 4677097 (1987-06-01), Omura et al.
Chem. Pharm. Bull, vol. 37, No. 10 (1989), pp. 2701-2709, T. Sunazuka et al .

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