Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-01-20
2000-09-26
Travers, Russell
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514210, 514385, 514256, 514422, 51421201, 514218, A61K 31395, A61K 31415, A61K 31505, A61K 3140, A61K 3155
Patent
active
061243191
ABSTRACT:
The present invention is directed to 3,3-disubstituted piperidines of the formula I: ##STR1## (wherein X, Y, Z, Ar, R, m and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, and/or CXCR-4.
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Maccoss Malcolm
Mills Sander G.
Merck & Co. , Inc.
Rose David L.
Thies J. Eric
Travers Russell
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