3,3-Diphenylpropylamines, their use and preparation

Details 3,3-Diphenylpropylamines, their use and preparation 3,3-Diphenylpropylamines, their use and preparation

2007-05-29

2007-05-29

Chang, Celia (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S086000, C564S165000, C564S316000, C546S240000, C548S578000, C514S315000, C514S317000, C514S408000, C514S603000, C514S620000

Reissue Patent

active

11017635

ABSTRACT:
The invention relates to 3,3-diphenylpropylamines of formula (I), wherein R1signifies hydrogen or methyl, R2and R3independently signify hydrogen, methyl, methoxy, hydroxy, carbamoyl, sulphamoyl or halogen, and X represents a tertiary amino group of formula (II), wherein R4and R5signify non-aromatic hydrocarbyl groups, which may be the same or different and which together contain at least three carbon atoms, and wherein R4and R5may form a ring together with the amine nitrogen, their salts with physiologically acceptable acids and, when the compounds can be in the form of optical isomers, the racemic mixture and the individual enantiomers. The invention also relates to methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs

REFERENCES:
patent: 3446901 (1969-05-01), Jones et al.
patent: 4139537 (1979-02-01), Diamond et al.
patent: 5382600 (1995-01-01), Jonsson et al.
patent: 5686464 (1997-11-01), Johansson et al.
patent: 6538035 (2003-03-01), Gillberg et al.
patent: 1 216 318 (1966-05-01), None
patent: 111894 (1968-10-01), None
patent: 1169944 (1969-11-01), None
patent: 1169945 (1969-11-01), None
patent: 215 499 (1967-09-01), None
patent: WO-89/06644 (1989-07-01), None
patent: WO-94/11337 (1994-05-01), None
Nilvebrant et al. “Tolterodine—a new bladder selective muscarinic . . . ” CA 126:271639 (1997).
Trilateral project B3b “Reach through claims” (2001).
Wilbraham “Organic and biological chemistry” p. 268-269 (1984).
Markaryan et al., Chemical Abstracts 97:120105n, vol. 97 (1982), p. 20.
Strehike et al., Chemical Abstracts 91:107943r, vol. 91 (1979), p. 580.
Atwal et al., Substituted 1,2,3,4-Tetrahydroaminonaphthols: Antihypertensive Agents, Calcium Channel Blockers, and Adrenergic Receptor Blockers with Catecholamine-Depleting Effects. Journal of Medicinal Chemistry 30:627-635 (1987).

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