3(2H)Pyridazinone, process for its preparation and anti-allergic

Details 3(2H)Pyridazinone, process for its preparation and anti-allergic 3(2H)Pyridazinone, process for its preparation and anti-allergic

1986-04-22

1990-01-09

Berch, Maril L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544241, C07D23722, A61K 3150

Patent

active

048929476

ABSTRACT:
A 3(2H)pyridazinone of the formula: ##STR1## wherein R.sub.1 is hydrogen, methyl, C.sub.3 -C.sub.6 alkenyl, C.sub.5 or C.sub.6 cycloalkyl, benzyl, phenyl, --(CH.sub.2).sub.m CO.sub.2 R.sub.3 (wherein R.sub.3 is hydrogen or C.sub.1 -C.sub.5 alkyl, and m is an integer of from 1 to 4), --(CH.sub.2).sub.n A (wherein A is --OH or --N(R.sub.4).sub.2 wherein R.sub.4 is C.sub.1 -C.sub.3 alkyl, and n is an integer of from 2 to 6) or --CH.sub.2 CF.sub.3 ; R.sub.2 is chlorine or bromine; each of Y.sub.1 and Y.sub.2 which may be the same or different, is hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.2 -C.sub.8 alkenyl, halogen, --OR.sub.5 (wherein R.sub.5 is hydrogen, C.sub.1 -C.sub.8 alkyl or ##STR2## wherein q is an integer of from 1 to 4), --CO.sub.2 R.sub.6 (wherein R.sub.6 is hydrogen or C.sub.1 -C.sub.5 alkyl), --N(R.sub.7).sub.2 (wherein R.sub.7 is C.sub.1 -C.sub.4 alkyl) or --SR.sub.8 (wherein R.sub.8 is C.sub.1 -C.sub.4 alkyl); and Y.sub.3 is C.sub.1 -C.sub.5 alkyl, C.sub.2 -C.sub.8 alkenyl, halogen, --OR.sub.5 (wherein R.sub.5 is as defined above), --CO.sub.2 R.sub.6 (wherein R.sub.6 is as defined above), --N(R.sub.7).sub.2 (wherein R.sub.7 is as defined above) or --SR.sub.8 (wherein R.sub.8 is as defined above), or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 3317531 (1967-05-01), Nachoneder
patent: 4783462 (1988-11-01), Mutsukado
Bourdais, Chem. Abs., 62, 2772(f), 1965.
Matsuo, Chemical Abstracts, vol. 89, 1978, p. 656, Abstract No. 24341a, Columbus, Ohio, U.S.; (1978).
Bulletin De La Societe Chimique De France, No. 9, 1964, pp. 2124-2132, Paris, Fr; J. Bourdais: "No. 342-Etudes en Serie Heterocyclique: III-Action des Amines Aliphatiques et Arylaliphatiques Sur Les Dihalogeno-4,5 (2h)-Pyridazinones-3" * pp. 2124, 2125, 2126(Table II), 2127*.

Affiliated with

Also associated with

Rating

3(2H)Pyridazinone, process for its preparation and anti-allergic does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 3(2H)Pyridazinone, process for its preparation and anti-allergic, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3(2H)Pyridazinone, process for its preparation and anti-allergic will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-146101