3(2H)pyridazinone, and anti-allergic agent containing it

Details 3(2H)pyridazinone, and anti-allergic agent containing it 3(2H)pyridazinone, and anti-allergic agent containing it

1986-02-27

1988-11-08

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544238, 544239, C07D23706, A61K 3150

Patent

active

047834625

ABSTRACT:
A 3(2H)pyridazinone of the formula: ##STR1## wherein R.sub.1 is hydrogen or C.sub.1 -C.sub.5 alkyl; R.sub.2 is hydrogen, C.sub.1 -C.sub.8 alkyl, chlorine or bromine; A is --NR.sub.3 -- or --O--; X is --(CH.sub.2).sub.n --, --CH(OR.sub.4)--, --CO-- or a single bond; when X is --(CH.sub.2).sub.n -- or a single bond, B is --O--, --S--, --NH--, --OSO.sub.2 --, or --OCO-- or a single bond, when X is --CH(OR.sub.4)--, B is --O--, --S--, --NH-- or --OSO.sub.2 --, and when X is --CO--, B is --O-- or --S--; and each of Y.sub.1, Y.sub.2 and Y.sub.3 which may be the same or different, is hydrogen, C.sub.1 -C.sub.8 alkyl, C.sub.2 -C.sub.8 alkenyl, halogen, ##STR2## or two of Y.sub.1, Y.sub.2 and Y.sub.3 together form ##STR3## and a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 4115575 (1978-09-01), Foei et al.
patent: 4360672 (1982-06-01), Parg
patent: 4558128 (1985-12-01), Ganelin et al.
Chemical Abstracts, vol. 78, No. 11, Mar. 19, 1973, Columbus, OH., USA-Karklina, A.; Gudriniece, E. "Reactions of 1-phenyl-4-nitro-5-chloro-6-pyridazone", p. 466, Column 1, abstract-No. 72 037a & Latv. PSR Zinat. Akad. Vestis, Kim. Ser. 1972(6), 718-21.
Chemical Abstracts, vol. 97, No. 7, Aug. 16, 1982, Columbus, OH., USA-Matsuo, Toshiyasu et al. "Synthesis and Biological Activity of Pyridazinooxazines" p. 646, column 1, abstract-No. 55 755h & Chem. Pharm. Bull. 1982, 30(3), 832-42.
Chemical Abstracts, vol. 89, No. 3, Jul. 17, 1978, Columbus, OH., USA-Matsuo, Toshiyasu et al. "Pyridazinone derivatives" p. 656, column 1, abstract-No. 24 341a & Japan. Kokai 78 12, 880.
Bulletin De La Societe Chimique De France, vol. 9, No. 342, pp. 2124-2132, Paris, Fr: J. Bourdais: "Etudes en Serie heterocyclique: III-Action des amines aliphatiques et aryl-aliphatiques sur les dihalogeno-4,5(2H)-pyridazinones--3".

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