Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1975-09-12
1977-03-29
Meyers, Albert T.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
A61K 3147
Patent
active
040150062
ABSTRACT:
New 2-substituted-3(2H)-isoquinolones and 2-substituted-3-alkoxyisoquinolines are disclosed. They are orally active hypotensives and peripheral vasodilators with an extended duration of action. Representative embodiments of this invention are 6,7-dimethoxy-2-methyl-1-veratryl-3(2H)-isoquinolone hydrochloride, 2-allyl-6,7-dimethoxy-1-veratryl-3(2H)-isoquinolone hydrochloride, 2-cyclopropyl-6,7-dimethoxy-1-veratryl-3(2H)-isoquinolone hydrochloride, 2-amino-6,7-dimethoxy-1-veratryl-3(2H)-isoquinolone hydrochloride, and 3-ethoxy-6,7-dimethoxy-1-veratrylisoquinoline.
REFERENCES:
patent: 2683713 (1954-07-01), Shepard
patent: 2728769 (1955-12-01), Shepard
Dorofeenko, et al. Jour. Gen. Chem. USSR, vol. 40, p. 230 (1970).
Elliott, Jour. Hetero. Chem., vol. 7, pp. 1229-30 (1970).
Comer William T.
Kreighbaum William E.
Carnahan Robert E.
Mead Johnson & Company
Meyers Albert T.
Stephens Daren M.
Uloth Robert H.
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